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Centessa Pharmaceuticals is the latest firm to explore whether an asset-centered model can make the process of bringing drugs to market cheaper and faster.

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Two workers move a 100 L glass reactor through Nano One's Montreal lithium iron phosphate factory.
Nano One Materials's Montreal factory, originally commissioned in 2012, is the only facility in North America that can produce meaningful quantities of lithium iron phosphate. Credit: David Giral Photography

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The American Chemical Society Division of Business Development and Management (BMGT) has established a new divisional award aimed at recognizing excellence within the service to, and execution of, leadership and management of the chemical industry. The BMGT Nexus Award was established to recognize strategic, outstanding, and sustainable contributions to BMGT by members of the division. The newly established award adds to the division’s strong portfolio in combination with the Nina I. McClelland Emerging Leader Award and the Henry J. Whalen Jr. Award for Excellence. All awards are open for applications through Feb. 14. More information can be found at bmgt.org/awards.

Centessa Pharmaceuticals is the latest firm to explore whether an asset-centered model can make the process of bringing drugs to market cheaper and faster. Founded by the life sciences investment firm Medicxi, Centessa launches with $250 million in funding from a venture syndicate and a diverse collection of drug programs.

Two workers move a 100 L glass reactor through Nano One's Montreal lithium iron phosphate factory.
Nano One Materials's Montreal factory, originally commissioned in 2012, is the only facility in North America that can produce meaningful quantities of lithium iron phosphate. Credit: David Giral Photography

An asset-centered model of drug development centralizes management and resources such as manufacturing and regulatory support around sometimes disparate programs. The hope is that experienced managers can guide programs with efficiency. At Centessa, managers include former Big Pharma executives like its CEO, Saurabh Saha, and chief scientific officer, Moncef Slaoui, who led R&D at Bristol Myers Squibb and GlaxoSmithKline, respectively.

Centessa brings together 10 private biotech firms—each focused on a single asset or biological pathway—under its management umbrella. The end result is a pipeline encompassing a range of diseases and featuring four clinical-stage drug candidates.

Centessa is not the first firm to house a collection of drug discovery programs under one management roof. Other examples of the approach include PureTech Health and BridgeBio Pharma.

PureTech founder and CEO Daphne Zohar argues that the model offers advantages over the conventional biotech setup, including efficiency with capital; flexibility in how assets are developed, whether alone, through partnerships, or spun out into their own entities; and the freedom to make decisions more objectively. “Unlike a biotech where everything rides on one or two programs and there’s a built-in bias to push programs forward, we have set up incentives to kill programs early so we can move resources to the successful ones,” Zohar says.

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